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What Does Ghrelin Do?
Ghrelin Acetate is a research peptide that is also called Lenomorelin. Ghrelin acetate comes from the natural peptide hormone produced in the gastrointestinal tract. The primary role of the ghrelin hormone is to promote food intake. It is referred to as the hunger hormone. In addition to food intake, ghrelin acetate promotes GI motility, growth hormone release, and gastric acid secretion. Further research shows ghrelin acetate has a primary role in sleep and wake behavior, glucose metabolism, learning, memory, and taste. Ultimately, the focus on ghrelin is changing the psychological behavior in eating and food preferences.
History – The Discovery of Ghrelin Acetate
A. T. Pitavast’s original paper in the Journal of Biological Chemistry, revealed the ability of ghrelin in causing increased food intake in rats. The same paper reports the ability of ghrelin to increase gastric acid secretion in rodents and in humans. These two discoveries are often regarded as the “birth of ghrelin” and are credited to Dr. Pitavast. In a later paper published in 1994, A. T. Pitavast showed ghrelin could stimulate growth hormone production in humans and suggested that ghrelin may play a role in promoting weight gain in rodents.
Ghrelin Acetate has been known to increase the food consumption, decrease the body fat, and regulate bone growth and metabolism. Ghrelin may work as a natural appetite stimulant. In humans, however, its physiological function still remains unknown.
Ghrelin is a hormone that stimulates hunger for the treatment of cancer patients and loss of appetite and weight.
Between 60% and 80% of cancer patients suffer from losing appetite and weight. Ultimately, this is associated with reducing life expectancy and quality of life. Ghrelin, a hormone that stimulates hunger. It is secreted by the stomach and other organs in the body. Studies reveal that ghrelin can treat loss of appetite and weight loss in cancer patients. However, the effectiveness and safety of ghrelin is not yet proven in such patients. In this review, we examine all the evidence on the efficacy and safety of ghrelin in improving appetite and body weight in people with cancer and loss of appetite and weight.
Characteristics of the studies
Three studies recruited 59 cancer patients (37 men and 22 women) aged between 54 and 78 years. Forty-seven cancer patients completed treatment. The studies differed in study design and included patients with various types of cancer. The studies also discussed dosage, injection route, frequency and duration of treatment. One study compared ghrelin with placebo, while two studies compared different doses of ghrelin (higher amount versus lower dose). Outcomes of interest for cancer patients with appetite and weight loss, such as improvement in food consumption and body weight, were not adequately reported.
Government agencies funded all three included studies. One study received an additional grant from a pharmaceutical company.
There is no evidence that ghrelin administration alone or in combination resulted in changes in body weight. No conclusion could be reached about its side effects. The limited amount of information means that no conclusions could be drawn.
Quality of the evidence
The quality of evidence from studies is graded on four levels: high, moderate, low, or very low. High-quality evidence means that experts are very confident in the results. Very low-quality evidence suggests that we are very uncertain about the results. The evidence in this review was of deficient quality.
There is insufficient evidence to support or refute the use of ghrelin in patients with cancer-related cachexia. Adequate powered randomized controlled trials focusing on evaluating the safety and efficacy of ghrelin in patients with cancer-related cachexia are warranted.