This blog looks at how an AICAR dosage enhances metabolism; maintains muscle tone; retains muscle mass; maintains a high athletic form even without training. Today AICAR supplement is widely used as an effective replacement for traditional doping in sports, where strength and endurance are no less, and sometimes even more important, than lead fighting. AICAR has a tremendous effect when athletes involved in any outdoor sports, from running to the football, are forced to skip training. Taking the substance allows the maintenance of muscle mass and excellent physical shape in general without any physical exertion and recovery processes.
Benefits of AICAR Dosage
The fundamental difference between AICAR and other substances is that it does not possess psychostimulating or tranquilizing properties. But it works by changing the activity of muscle genes. In addition, it is not addictive. AICAR reviews indicate that it is very effective for those who monitor their physical condition in the body. In addition, AICAR is ideal for people who, for health reasons or due to lack of free time, are not able to fully engage in sports. The laboratory of Ronald Evans in California, which more than once made breakthroughs in the field of genetics and biochemistry, continues to work on improving the drug.
The Science of AICAR
AICA ribonucleotide or AICAR or aminoimidazole carboxamide ribonucleotide is an intermediate in the generation of inosine monophosphate. This acts as an agonist of AMP-activated protein kinase (AMPK). The research peptide Aicar stimulates glucose uptake in skeletal muscles. It increases the expression of p38-mitogen-activated protein kinase types a and β. Also, it prevents the process of apoptosis by inhibiting the formation of free radicals, primarily reactive atomic oxygen, inside the cell. It should be noted that a long time ago, theoretical biochemists at the molecular level established a connection between the action of AMPK and the functioning of Na + -K + -ATPase (sodium-potassium pump). This hydrolyzes 25% of all ATP reserves in the cell to form energy. Therefore, AMPK activity is a hypersensitive energy sensor.
The Story of Peptides
Several years ago, the Howard Hughes Institute (MIGH, USA), which supports leading biomedicine scientists from 10 countries of the world, announced the discovery of chemical compounds. The action of which allows a person to maintain high athletic form even without training. These compounds are known as research peptides. Peptides are short proteins, the chains of which do not consist of the usual tens of amino acids, but only two or three links. Peptides are extracted from various organs or body parts of mammals. Therefore the human body accepts them as its own, after which they enter into targeted interaction with the necessary object.
Why Were Peptides Created?
Initially, research into the possibilities of peptides was dictated by military objectives. Scientists wanted to find a safe and effective way to increase the body’s resistance in extreme conditions, and thereby, increase the combat capability of a soldier. Work in this direction was also carried out by our compatriots, professors of the Military Medical Academy Vladimir Khavinson and Vyacheslav Morozov back in the 70s of the 20th century. Ronald Evans and his fellow biochemists put an end to the long-term research of the sports grail.
AICAR Fat Loss
Peptides are different, some accelerate the process of cell renewal, others increase immunity or optimize blood supply, improve vision or liver function, etc. Among them, there are those that increase metabolism and affect the muscles in the same way as playing sports for many hours. The substance based on this type of peptides was named AICAR. The peptide received its name in the form of an abbreviation from the scientific name of a peptide extracted from the femoral muscle, which is called 5-aminoimidazole-4-carboxamidribofuranoside. AICAR provides an almost 50% increase in stamina and the rate of consumption of fats (lipids), which are known to serve as a fuel energy source.
AICAR Dosage and Storage
Storage conditions for AICAR powder are as follows – Store at a temperature of 2-8 C degrees or in the refrigerator. If AICAR is dissolved the solution should be stored in the refrigerator. The mode of application is intramuscular or subcutaneous injections.
The optimal single dose in the absence of activity is 100 mg of the drug with a frequency of administration every other day, or alternatively: 50-100 mg with a frequency of administration 3-4 times a week. The course of admission is up to 30 days. In sporting cases, AICAR is taken 15-20 mg daily, depending on the volume of muscle mass, for 30 days. After a break of 1-2 months, the course can be repeated, but not more than 3 courses per year.
Summary of AICAR Effects
Whilst in this article we have discovered Aicar dosage has many positive effects in building muscle and improving performance. We must point out that this is just information and whilst it was once used in the past by sportspeople it is in fact now a banned substance by WADA (World Anti-Doping Agency). AICAR has not had enough testing inpatients and is not for use in humans. AICARside effects can be serious, resulting in problems such as neurodegeneration and metabolic disorders. The peptide AICAR is widely available from reputable suppliers but for research purposes only!