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Ozempic vs Tirzepatide For Weight Loss – Which Works Best?

Ozempic vs Tirzepatide For Weight Loss

Ozempic vs Tirzepatide for weight loss, is a common question amid the research community. So in this post we explore the difference and find out which one is good for weight loss.[1] Plus, for those in the research industry advise the where to buy tirzepatide for weight loss research and Semaglutide. 

Is Tirzepatide Or Ozempic Better For Weight Loss?

Both Semaglutide (brand name Ozempic) and Tirzepatide (brand name Mounjaro) [2] are research medications that have been investigated for their potential to promote weight loss. They belong to a class of drugs known as glucagon-like peptide-1 receptor agonists (GLP-1 RAs). Research has shown that these have helped with weight loss in addition to their primary use in managing blood sugar levels in people with type 2 diabetes.


Clinical Trial Results – Tirzepatide vs Semaglutide For Weight Loss

Both tirzepatide and Ozempic have demonstrated significant weight loss benefits in clinical trials. Tirzepatide, in particular, has shown impressive weight loss results in some trials, often surpassing those of Ozempic.[3]

How Does Tirzepatide Work?

Tirzepatide is a dual GLP-1 and GLP-2 receptor agonist, which means it affects both glucagon-like peptide-1 (GLP-1) and glucagon-like peptide-2 (GLP-2) receptors. GLP-1 receptor activation promotes weight loss, but the added GLP-2 activity may provide additional benefits. Ozempic which contains the substance semaglutide is primarily a GLP-1 receptor agonist.[4]

Dosage and Administration

Tirzepatide and Ozempic are both administered as weekly. The ease of use and patient preferences for frequency may be factors to consider.

Side Effects

Both medications can have side effects, which can include nausea, vomiting, diarrhea, and other gastrointestinal symptoms. Tolerability of these side effects can vary from person to person, so it’s essential to discuss this with your healthcare provider.

Cost and Insurance Coverage

The cost of these medications and whether your insurance covers them can influence your choice. Some insurance plans may have preferred medications or formularies that affect your out-of-pocket costs.

Individual Health Factors

Your overall health, any preexisting medical conditions, and other medications you are taking should be considered when choosing a weight loss medication. Your healthcare provider can help determine which medication may be more suitable based on your specific health profile.

It’s important to emphasize that a professional should make a choice between Mounjaro (tirzepatide) and Ozempic (semaglutide). These can consider your unique circumstances and provide personalized guidance.

Tirzepatide vs Semaglutide For Weight Loss

Tirzepatide and Semaglutide are research medications originally developed to treat type 2 diabetes. In recent years, studies have shown their potential in aiding weight management. Both drugs can help reduce appetite, but their differences and comparative effectiveness are still subjects of ongoing research. It’s crucial to note that using these medications for weight loss is considered “off-label,” meaning they are prescribed for a different purpose than their FDA-approved use.[5]

Ozempic vs Tirzepatide For Weight LossSemaglutide (Ozempic, Wegovy, and Rybelsus)

Semaglutide is FDA-approved for treating type 2 diabetes, with Wegovy being the brand approved for weight management.

It falls into the class of drugs known as glucagon-like peptide-1 (GLP-1) receptor agonists, mimicking the GLP-1 hormone to reduce hunger and promote feelings of fullness.
Available in both oral tablet and other forms.[6]

Tirzepatide (Mounjaro)

Tirzepatide is a glucose-dependent insulinotropic polypeptide (GIP) and GLP-1 receptor agonist, mimicking both the GLP-1 and GIP hormones.

This dual action may provide an extra weight loss boost, but it is only FDA-approved for type 2 diabetes, making any weight loss use “off-label.”

Effectiveness Of Tirzepatide For Weight Loss

As of 2023, recent studies suggest that tirzepatide may lead to greater weight loss than semaglutide. However, it’s essential to consider that these medications were not equal in these studies, with tirzepatide administered at a higher level.

While these studies focused on individuals with type 2 diabetes, semaglutide has also shown potential as a weight loss treatment for those without diabetes.

Tirzepatide vs Ozempic Side Effects

Both tirzepatide and semaglutide share similar side effects due to their similar mechanisms of action.
Common moderate side effects include constipation, diarrhea, upset stomach, nausea, vomiting, headaches, abdominal pain, fatigue, and low blood sugar (hypoglycemia).

More severe side effects can include vision changes, pancreatitis, kidney issues, gallbladder problems, and allergic reactions.

Both medications carry boxed warnings for the risk of thyroid C-cell tumors, the most severe warning issued by the FDA.

Tirzepatide Warning

It’s important to note that there is still uncertainty regarding the side effects of tirzepatide in individuals without type 2 diabetes. Further research is needed! Tirzepatide is a research peptide and only available for educational and development use. It is not for human use.

Ozempic vs Tirzepatide For Weight Loss – Most Frequently Asked Questions

What Is Stronger Than Ozempic For Weight Loss?

In some research studies, Tirzepatide (Mounjaro) has demonstrated greater effectiveness in promoting weight loss than Ozempic. A recent study conducted over 40 weeks found that the higher amounts of Tirzepatide (15 mg) led to almost twice as much weight loss compared to Ozempic at a 1 mg. These findings suggest that Tirzepatide may be a more potent option for weight loss than Ozempic in certain situations.[7]

How Fast Do You Lose Weight On Tirzepatide?

Individuals using Mounjaro (Tirzepatide) typically experience significant weight loss, with an average of 15% to 20% of their initial body weight lost over 72 weeks, equivalent to about 34 to 48 pounds. Thus, these translate into a consistent and notable weight loss over approximately 16.5 months.

Does Tirzepatide Burn Fat?

Tirzepatide facilitates the conversion of stored fat into energy, making it particularly beneficial for individuals aiming to reduce body fat. By promoting the mobilization and utilization of stored fat as an energy source, Tirzepatide can contribute to accelerated weight loss and a more effective reduction in body fat percentage.

Will My Doctor Prescribe Tirzepatide For Weight Loss?

While Mounjaro (tirzepatide) is prescribed to manage blood sugar and promote weight loss in individuals with type 2 diabetes, some doctors may consider prescribing it off-label for obesity treatment. However, it’s important to note that tirzepatide does not have FDA approval specifically for weight loss or obesity management. You can obtain a prescription for Mounjaro either through in-person consultations with healthcare providers or through authorized online sources.

How Much Does Tirzepatide Cost Monthly?

As with all medication Tirzepatide vs Ozempic cost can vary.  According to a 2023 study, the monthly cost for tirzepatide was $974, while semaglutide was slightly lower at $892. These costs were determined based on wholesale acquisition prices at the time of the analysis. It’s worth noting that the total expenses were higher for individuals receiving Mounjaro (tirzepatide) than those using Ozempic (semaglutide).[8]

Is Tirzepatide Available In the UK?

Tirzepatide has received approval in the UK for weight loss in individuals dealing with obesity. While the precise availability date of Mounjaro in the UK remains uncertain, it is anticipated that it may become widely accessible, as early as January 2024.

When Will Tirzepatide Be Available?

Zepbound, which contains tirzepatide, received FDA approval on November 8, 2023. It is expected to be accessible to individuals in the United States by the end of the same year. 

Conclusion To Ozempic vs Tirzepatide For Weight Loss

In comparing Ozempic (semaglutide) and Mounjaro (tirzepatide) for weight loss, it is evident that both medications have demonstrated promising results in clinical trials.

Tirzepatide has shown the potential for significant weight loss and may offer an extra weight loss boost due to its dual action on GLP-1 and GIP receptors. Nevertheless, it is currently only FDA-approved for type 2 diabetes.
On the other hand, semaglutide, precisely the Wegovy formulation, has received FDA approval for weight management. It is available in both oral tablet and needle forms, providing flexibility in administration.

Ultimately, the decision between Ozempic and Mounjaro should be based on a comprehensive evaluation by a professional, considering the latest research findings, individual health needs, and potential benefits and risks associated with each medication.



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[1] Mounjaro More Effective Than Ozempic for Weight Loss, New Research Shows

[2] Lilly’s tirzepatide achieved up to 15.7% weight loss in adults with obesity or overweight and type 2 diabetes in SURMOUNT-2

[3] Mounjaro vs Ozempic: How do these weight loss medications stack up?


[5] The next big weight-loss drug is a huge leap forward from Ozempic

[6] SEMAGLUTIDE for weight loss

[7] Understanding Ozempic® vs. Mounjaro® for Weight Loss

[8] How Much Does Mounjaro Cost In the UK?