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How Does Tirzepatide Work?
Tirzepatide is an agonist of glucose-dependent insulin tropic peptide (GIP) and glucagon-related peptide-1 receptor (GLP-1). When taken once a week, it combines the action of both incretins in a new molecule. GIP is a hormone and compliments the GLP-1 receptor agonists effects.
In preclinical models, GIP can reduce food intake and increase energy expenditure, leading to weight loss. It may have more pronounced effects on blood sugar and body weight when combined with a GLP-1 receptor agonist. Tirzepatide in a phase III study looking at blood sugar management in adults with type 2 diabetes and long-term weight management. It is also testing as a potential treatment for non-alcoholic steatohepatitis.
Tirzepatide Brand Name
Tirzepatide is a research peptide that derives from the gastric inhibitory polypeptide (GIP). It is similar in functionality to glucagon-like peptide-1 or GLP-1 .
Tirzepatide was initially made to fight type 2 diabetes. But, continuing studies are showing it can protect the heart, and boost weight loss.
In fact Tirzepatide is available now as a type 2 diabetes medication under the brand name of Mounjaro.
Continuing studies are showing it can protect the heart, and boost weight loss. The Tirzepatide injection is given under the skin to treat diabetes.
Tirzepatide side effects can include:
-abdominal pain and discomfort
Safety problems did not appear to have arisen in the study. According to the manufacturer, the side effect profile is comparable to other incretin-based therapies. The most common were nausea (31.0% in the highest dose versus 9.5% in the placebo group), diarrhea (23.0% versus 7.3%), vomiting (12.2% versus 1.7%) and constipation (11.7% versus 5.8%).
At the highest dose level, 6.2% of participants discontinued treatment prematurely due to side effects. The overall dropout rate was 14.3% versus 26.4% in the placebo group (presumably due to lack of success).
Tirzepatide Weight Loss
The combined GIP/GLP-1 agonist tirzepatide achieved a weight loss of more than 20% in a study using the highest dose in obese patients.
The glucose-dependent insulin tropic peptide (GIP) and the glucagon-like peptide (GLP-1) form by different cells in the intestine during meals. The two hormones not only promote the release of insulin, which is why they are referred to as incretins (“intestinal secretion of insulin”). They also slow gastric emptying and decrease appetite.
Treatment with the various incretins that have been approved for the treatment of type 2 diabetes in recent years often leads to weight loss, which was initially interpreted as a welcome side effect. Incretins are now also being clinically tested for the treatment of obesity. Semaglutide, a GLP-1 agonist for the treatment of obesity, was approved last year in the United States and recently also in Europe.
Weight loss is comparable to that after bariatric surgery, which is 15% to 25% for gastric bypass. In contrast to surgery, treatment with tirzepatide will probably have to be carried out over the long term, which is likely to involve considerable costs.
Tirzepatide FDA Approval
From May 2022 the FDA approved Mounjaro (tirzepatide) as a medication for adults with Type 2 diabetes. It is a new class of diabetes treatment combining GIP and GLP-1 receptor agonists.
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Tirzepatide is showing good results in treating serious health issues from diabetes to obesity. We supply the research product tirzepatide for study only. Our website is among the leading research suppliers online with a vast selection to buy. We supply premium quality research products that are additive and TFA free. The products are safe and pure and made in the USA.