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thymosin alpha 1 peptide buyThymosin alpha 1 peptide cost with Peptide Sciences is competitive with leading USA research companies. If you are in the research industry then don’t miss out on the opportunity to buy the best grade research peptides. The research chemicals are all tested to guarantee 99% purity. This is means you are getting the very best quality research chemicals for all of your study needs. Thymosin Alpha 1 Peptide buy 10mg today at the affordable cost of $130.00!

What is Thymosin Alpha 1 Peptide?

Thymosin alpha is a tiny protein made in the thymus gland naturally. The thymus is where T cells mature and release when prompted to do so by the T α 1 peptide. The T cell production and activity in the body are essential for immunity. With this action, immune cells can recognize and get rid of foreign invaders. In particular, studies with T α 1 can enhance specific immune cells function cells called T and dendritic cells. These are white blood cells and are the body’s defense process to people suffering from an infection or a depressed immune system.

Thymosin alpha 1 Peptide Benefits

  • Improves the workings of specific cells called T and dendritic cells
  • It gets rid of unhealthy cells and stops cancer growth and infection
  • Reveals antibacterial and antifungal properties
  • Stems tumor growth
  • Better vaccine effectiveness
  • Protects against oxidative damage

The two cell forms are:

  • T cells are capable of hunting down and destroying infected and cancerous cells.
  • Helper cells unite with other cells in the immune system to orchestrate and carry out appropriate immune responses.

Thymosin Peptide Injection

Thymosin alpha 1 peptide is a research product in the USA. It is approved for use in over 37 countries as an addition to chemotherapy and certain vaccines.

Thymosin alpha 1 is an active ingredient in the medication Zadaxin used in hepatitis B and C treatment. It is extensively tested for its supporting the immune system that is blocked by chemotherapy in cancer patients.

Research with Thymosin alpha 1 peptide shows indications of it being effective in treating malignant melanoma, hepatocellular carcinoma, drug-resistant tuberculosis, chronic fatigue, and Di George’s syndrome, as well as any chronic cancer or viral disease.

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Thymosin Alpha 1 buy online for study use in laboratories. As with all research chemicals, there is still a lot more testing to do before some countries permit it for use in pharmaceuticals. There are strict laws with the research products and they are not for use on humans. If you are in the research community make sure you buy from us today. Our research chemicals have all undergone strict testing to provide the very safest products for research.

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Further studies with Thymosin Alpha 1 Peptide

A study led by researchers at George Washington University has just identified a potential new treatment for cystic fibrosis. The therapy on thymosin alpha-1, a synthetic peptide that replicates a naturally produced peptide, reduces the inflammation seen in cystic fibrosis patients and improves the activity and stability of the CFTR protein responsible for the disease.

Cystic fibrosis is an autosomal recessive disease caused by mutations in the gene that code for the CFTR protein. Alterations in CFTR compromise the production or activity of an ion transporter in the cell membrane. The most frequent mutation, p.Phe508del, gives rise to a CFTR protein with limited movement, which does not fold correctly and leads to cell permeability and inflammation in the affected organs, mainly the lungs.

Although there are treatments to deal with cystic fibrosis, which have increased the life expectancy of patients, there is no treatment that works together against the different effects of CFTR alteration. “No treatment works alone,” says Allan Goldstein, director of the work. “We have developed a unique treatment that can potentially correct the genetic defect that causes cystic fibrosis and decrease the inflammation that occurs as a result.”

Thymosin alpha 1 Dosage

Thymosin alfa is approved as an ingredient under the trade name Zadaxin, which favors its use in future clinical trials with patients with cystic fibrosis.

The researchers used a mouse model for cystic fibrosis, administered thymosin alfa. This naturally occurring polypeptide acts as an immune modulator and is clinically safe when used as an immunotherapeutic or adjuvant agent. The work results showed that thymosin alfa improves inflammation and immune tolerance in mice carrying the p.Phe508del mutation in CFTR. Furthermore, the polypeptide improved the localization, stability, and function of the mutant CFTR protein through different mechanisms, both in mutant mice and in cells of human patients with the mutation.

Thymosin Alfa is a potential therapeutic agent for the treatment of cystic fibrosis. For the first time, a single compound can treat two characteristics of the disease, namely inflammation, and impaired CFTR function.

Summary – Thymosin alpha 1 Peptide Buy for research

The researchers acknowledge that the corrective activity of thymosin alpha has yet to be confirmed and evaluated against other compounds in development. In some areas, thymosin alfa is already approved under the trade name Zadaxin and is used in adults and children.

The cost-effectiveness of this peptide suggests that it could be used in further clinical trials to evaluate its effectiveness in cystic fibrosis patients.

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What is Thymosin Alpha 1?

Thymosin alfa-1 (thymalfasin) is a synthetic peptide with immunomodulatory activity. Thymosin alpha-1 (thymalfasin) is a synthetic peptide of 28 amino acids, with a molecular weight of 3,108. The mechanism of action of thymosin in the treatment of chronic hepatitis B and C. is not fully understood. It produces the promotion of T-cell maturation by mitogen-stimulated peripheral blood lymphocytes. In addition, it increases the production of various lymphokines such as interferon-alpha, interferon-gamma, interleukin 2 (IL-2), and interleukin 3 (IL-3) by T cells, following antigen or mitogen activation and increases receptor levels of lymphokines in T cells. It also increases the reactions of mixed halogenic and autologous human lymphocytes by activation of T4 cells (assistants/inducers). Also, it may influence the recruitment of natural killer (NK) cells, which become cytotoxic after exposure to interferon in vitro, thymosin alpha-1 (thymalfasin) increases IL-2 receptors and IL-2 production in concanavalin A-stimulated mouse lymphocytes.

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Studies with Thymosin Alpha 1

Clinical studies have shown that treatment with thymosin alpha 1 in patients with chronic hepatitis B and C (who have been seropositive for at least 6 months) with serum alanine aminotransferase (ALT) enzymes elevated, thymosin treatment produced remission of the plasma virus (HBV DNA negative) and normalization of serum aminotransferases. Thymosin alfa-1 (thymalfasin) is absorbed after subcutaneous application, reaching a maximum peak plasma concentration of approximately 25-30ng / ml at the time of administration with the recommended dose, maintaining these values ​​for approximately 6 hours.

An increase in plasma levels proportional to the dose is observed, both in the maximum plasma concentration (Cmax) and in the area under the curve (AUC). Plasma levels return to baseline 24 hours after administration. The plasma half-life (t½) is approximately 2 hours and there is no evidence of accumulation from multiple doses. Between 31% and 61% of a single dose is excreted in the urine.

Indications

Treatment of chronic hepatitis B in patients over 18 years of age with compensated liver disease and proven viral replication. Treatment of chronic hepatitis C, in patients over 18 years of age with compensated liver disease and demonstrated viral replication. Adjuvant to anti-influenza vaccination in immunocompromised subjects.

Thymosin Alpha 1 Dosage

In the treatment of chronic hepatitis B (monotherapy or combination therapy): 1.6mg (0.9mg / m2 of body surface area) subcutaneously 2 times a week for 6 to 12 months.

In the treatment of chronic hepatitis C (combined therapy): 1.6mg (0.9mg / m2) subcutaneously twice a week for 12 months.

Those patients weighing less than 40kg should receive a thymosin alfa-1 dose of 40 mg/kg. The dose of interferon alfa 2b will be that recommended in the treatment regimens for chronic hepatitis. In adjuvant anti-influenza vaccination in immunosuppressed patients: 1.6mg (0.9mg / m2) subcutaneously once a week for 4 weeks, starting from time zero (first vaccination). Treatment should be repeated from week 8 (second vaccination) to week 12. It should not be administered intramuscularly or intravenously.

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Thymosin Alpha 1 Side Effects

Thymosin alfa-1 is very well tolerated and its adverse reactions are rare. Occasionally a burning sensation at the injection site and very occasionally transient loss of muscle mass. Can be seen: fever, nausea. It may happen that at the beginning of treatment there is a transient increase in serum ALT, twice above the baseline level. In these cases, treatment can be continued unless other signs or symptoms of liver disease appear.

Cautions and Warnings

It should be used with caution in atopic subjects or with previous allergic reactions. In autoimmune diseases, the administration should be evaluated for each particular case. Mutagenic effects have not been demonstrated. Animal reproduction studies show no differences with control animals. It can only be administered to the pregnant woman if there is a clear need. It is unknown whether the drug is excreted in human milk. Safety and effectiveness have not been established in patients under 18 years of age.

Contraindications

Hypersensitivity to the active principle or to any other component of the formulation. Immunosuppression (unless the benefits outweigh the risks). Severe liver or kidney failure.