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What is Tesamorelin?
Tesamorelin is a synthetic growth hormone release factor and stimulates the pituitary gland in the brain to secrete growth hormones. Clinical studies have shown that tesamorelin significantly reduces abdominal fat but with fewer side effects than human growth hormone alone. However, abdominal fat may return after discontinuation of Tesamorelin. Tesamorelin is a synthetic peptide and contains all 44 amino acids of hGRF with the trans-3-hexenoic acid group.
What Does Tesamorelin Do?
The research peptide tesamorelin reduces lipodystrophy in HIV-infected people. Lipodystrophy is a condition that changes body fat distribution, including fat loss and accumulation and changes in metabolism.
Tesamorelin chemical structure
Tesamorelin is a growth hormone-releasing hormone or GHRH somatocrinin. It is a 44-amino acid endogenous peptide hormone released from the neurosecretory nerve terminals of these arcuate neurons in a pulsating manner. GHRH carries from the hypothalamic-pituitary portal system to the pituitary gland. There it binds to growth hormone-releasing hormone receptors and promotes the secretion of growth hormone by the pituitary gland.
Tesamorelin Mechanism of Action
Tesamorelin acts similarly to its natural analog GHRH in the anterior pituitary gland and attaches to growth hormone-releasing hormone receptors (GHRHR). This action causes growth hormone production by the pituitary gland. The growth hormone is effective by binding to the target cell receptors of various organs in the body, with the main target organ of growth hormone is the liver. Here the GH stimulates the production of IGF-1 or insulin-like growth factor 1.
Growth hormone production is associated with regulating many vital processes and functions in the body, primarily regulating anabolic and lipolytic mechanisms. However, studies show Tesamorelin reduces body fat mass by lipolysis, followed by lowering triglyceride levels.
Lipolysis is the process where fats are broken down in the body by the metabolic pathway. Lipid triglycerides hydrolyze to glycerol and three fatty acids.
Clinical Trials and Uses of Tesamorelin
Tesamorelin treats HIV-related lipodystrophy and reduces excess fat in the stomach caused by taking HIV medicines. (HIV-related lipodystrophy is a syndrome that occurs in HIV-infected patients treated with antiretroviral drugs.) Clinical studies have demonstrated that Tesamorelin significantly reduces belly fat with fewer side effects than HGH, although belly fat may return (depending on the individual) after discontinuation of Tesamorelin. Tesamorelin may cause damage to the fetus or congenital disabilities, so it should not use it if pregnant.
Tesamorelin Peptide Benefits
- Radically reduces belly fat
- Increases growth hormone secretion
- It can provide many other positive effects associated with elevated GH levels
Tesamorelin Peptide Side Effects
- Pain, redness, itching, swelling, and irritation from the injection site
- Numbness or tingling in the hands or fingers
- Swelling of the hands, ankles, or feet
- Pain or stiffness in muscles or joints
- Tesamorelin in pregnancy (category X) may cause damage to the fetus
- May cause glucose intolerance, high blood sugar or may increase the risk of type 2 diabetes.
Tesamorelin Dosage for Weight Loss
To date, there have been numerous clinical trials with tesamorelin. A typical example in clinical use to treat excess abdominal fat is a 2 mg Tesamorelin dosage by subcutaneous injection once daily in the abdomen.
Tesamorelin for sale
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