This guide takes a look at the research chemical Tesamorelin benefits as well as discovering how it works and what it can treat in the future in medicine! Tesamorelin peptide is a synthetic form of growth hormone-releasing hormone or GHRH. It contains all 44 human amino acids GHRH with the addition of a group of trans-3-hexenoic acid (N-terminally modified compounds based on GHRH). This modified synthetic research chemical is a stronger version and more stable than the natural endogenous peptide growth hormone-releasing hormone. Tesamorelin is also more resistant to cleavage than dipeptidyl aminopeptidase than human GHRH.
Tesamorelin Before and After – How it Works
Growth hormone-releasing hormone or GHRH; somatocrinin is a 44-amino acid endogenous peptide hormone released from the neurosecretory nerve terminals of these arcuate neurons in a pulsating mode. GHRH then carries from the hypothalamic-pituitary portal system to the pituitary gland, where it binds to growth hormone-releasing hormone receptors and stimulates the secretion of growth hormone by the pituitary gland.
Peptide Tesamorelin Mechanism of Action
The peptide Tesamorelin works similarly to its natural analog GHRH. In the anterior pituitary gland, it binds to growth hormone-releasing hormone receptors (GHRHR), which causes the production of growth hormone (GH) by the pituitary gland. The growth hormone then carries some of its effects by binding to the receptors of the target cells of various organs in the body; however, the main target organ of growth hormone is the liver, where GH stimulates the production of IGF-1 or insulin-like growth factor 1.
Tesamorelin for Weight Loss
Growth hormone production is associated with the regulation of many important processes and functions in the body, especially the regulation of anabolic and lipolytic mechanisms. However, it has been found that the main mechanisms by which Tesamorelin reduces body fat mass are lipolysis, followed by a reduction in triglyceride levels. Lipolysis is the process by which fats are broken down in the body, the metabolic pathway by which lipid triglycerides are hydrolyzed to glycerol and three fatty acids.
Clinical Trials – Tesamorelin Peptide Benefits
Tesamorelin is used to treat HIV-related lipodystrophy, to reduce excess fat in the stomach that is caused by taking HIV medicines. HIV-related lipodystrophy is a condition that occurs in HIV-infected patients treated with antiretroviral drugs. Clinical studies have confirmed that Tesamorelin drastically reduces abdominal fat with fewer side effects than HGH. But abdominal fat may return depending on the individual person after discontinuing of Tesamorelin dosage. Tesamorelin could cause damage to the fetus or birth defects, so it should not be used in pregnant women.
Scientific Tesamorelin Peptide Benefits
- Significantly reduces belly fat
- Increases the secretion of growth hormone
- It can provide many other positive effects associated with elevated GH levels
Possible Tesamorelin Side Effects
- Pain, redness, itching, swelling or other irritation at the injection site
- Numbness or tingling in the hands or fingers
- Swelling of the hands, ankles or feet
- Pain or stiffness in muscles or joints
- Tesamorelin is contraindicated in pregnancy as may cause damage to the fetus
- May cause glucose intolerance, high blood sugar or may increase the risk of type 2 diabetes
Clinical use for the treatment of excess abdominal fat is 2 mg Tesamorelin by subcutaneous injection once daily in the abdomen. Tesamorelin is classed as a research chemical and is still in the early stages of clinical trials. Whilst Tesamorelin benefits are beginning to surface there is still a long way to go before it is in mainstream medicine.