According to their chemical structure, hormones are divided into steroids and peptides. Steroid hormones are glucocorticoids, mineralocorticoids, sex steroids (androgens, estrogens, progestogens), and sterol hormones (vitamin D derivatives). There are many peptide hormones, that make the term peptide therapy. The most important among them are; adrenocorticotropic hormone (AKTH), anti-diuretic hormone (ADH), glucagon, gonadotropin-releasing hormone (GnRH), erythropoietin (EPO), and insulin-like (insulin-producing), luteinizing hormone (LH), thyroid-stimulating hormone (TSH), thyrotropin-releasing hormone (TRH), thyroxine (T4), triiodothyronine (T3), follicle-stimulating hormone (FSH), adrenaline, honoprynate (HGH), somatostatin, somatotropin-releasing hormone (GHRH) and ghrelin.
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The hormones listed above are secreted by the endocrine glands and activate a number of biochemical processes in the body. The secretion of these glands is stimulated or suppressed by hormones secreted by the pituitary gland. It (the pituitary gland) is a major endocrine organ in the human body. It directs the activity of all other glands in the human body, providing effective control over them.
In bodybuilding environments, the use of peptide hormones refers specifically to the use of hormones that stimulate the secretion of growth hormone (which in itself is also a peptide hormone). The secretion of growth hormone (HGH – human Growth Hormone) by the pituitary gland depends on 3 other hormones:
Somatostatin (GHIH – Growth Hormone Inhibiting Hormone), which is a retention hormone. It is separated from the hypothalamus.
Somatoliberin or Somatotropin-releasing hormone (GHRH – Growth Hormone Releasing Hormone), which is a stimulating hormone. It is separated from the hypothalamus.
Ghrelin (also known as the hunger hormone), is a modulating hormone and actually optimizes the balance between the other two hormones. It is secreted by the pancreas.
The problem with using GHRH analogs alone is that they are only effective when somatostatin levels are low. So it is imperative that they be combined with GHRP (Growth Hormone Releasing Peptide). This in turn creates a growth hormone pulse through a number of mechanisms such as a reduction in somatostatin release. The result of the combination of GHRP and GHRH analogs is a synergistic release of growth hormone. This means the releases is not total, and even more – in simple language when there is synergy, it means that 2 + 2 is not equal to 4, but 5).
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The most popular synthetic GHRPs are GHRP-6, GHRP-2, and Ipamorelin. They differ from each other in terms of saturation of the body’s sensitivity to them and in terms of the increase in prolactin and cortisol levels that accompanies their intake. Cortisol is a catabolic hormone, and prolactin in women increases lactation, and its high levels in the blood can cause infertility.
The maximum single dose of GHRP saturation (GHRP-6, GHRP-2, and Ipamorelin) in most medical studies is 100 mcg or 1 mcg/kg body weight. If you add another 100mcg per intake only 50% of them will be effective, with another 100mcg only 25%. Therefore, repeated use of GHRP during the day at 100mcg is more appropriate, as a single intake provides a pulse of growth hormone for only a few hours, and 100mcg is completely sufficient to saturate the receptors. GHRP-6 and GHRP-2 can be used 3-4 times a day in their saturated dose of 100mcg, without causing a decrease in sensitivity, and Ipamorelin even more.
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These differences make some of them more suitable for some purposes and others for other purposes:
GHRP-6 is the standard and most widely used of the three, and is suitable for both gaining muscle mass and burning fat. Its saturation dose is 100mcg and there is no noticeable increase in prolactin and cortisol levels. This occurs at higher doses, but again within normal limits. A disadvantage for those who want to burn fat and lose weight is the increased appetite that users feel in the first weeks. It is due to the fact that it increases the action of the hormone ghrelin (the hormone of hunger), which is released from the pancreas and is responsible for appetite and satiety.
GHRP-2 is stronger than GHRP-6, causing a stronger pulse of growth hormone. But at the same time, it raises prolactin and cortisol levels to a greater extent. It is important that even doses above the saturating level of 100mcg (such as 200-400mcg for example) do not exceed the permissible reference values for prolactin and cortisol. Its use is more appropriate during a period of increasing muscle mass, as slight water retention is possible.
Ipamorelin is as effective as GHRP-6 in inducing growth hormone pulse. At the same time, doses above its saturating 100mcg did not cause any increase in prolactin and cortisol levels.
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There is an abundance of research chemical companies online and there to supply to the research industry. All of these mentioned research chemicals are still very much in the early stages of clinical trials. But, many are showing positive results in treating age-related problems.