Tag: liraglutide weight loss nejm

Obesity is a growing problem globally. It causes numerous health problems that cost health systems millions of dollars every year.  In this post we look at the new weight loss treatment – LIRAGLUTIDE.  Liraglutide is a new drug on the research market to treat obesity. It helps reduce weight by affecting the area of our body that regulates appetite. Your doctor must prescribe its use.

Liraglutide, a research peptide initially designed for diabetes management, is now demonstrating remarkable potential in the realm of weight loss. Recent studies have revealed encouraging results, showcasing Liraglutide’s ability to induce significant weight loss by curbing appetite and promoting satiety. This peptide’s capacity to target specific hormonal pathways that influence metabolism has led to notable reductions in body weight and improved metabolic profiles. While further research is needed to solidify its long-term efficacy and safety, Liraglutide’s promising outcomes in weight loss could signify a groundbreaking advancement in the fight against obesity.

What Is Liraglutide And How Does it Work?

The drug is similar to a naturally occurring hormone released in the intestine after eating food. It activates receptors in the brain that control appetite, producing a feeling of fullness and decreased hunger. As a result, the patient eats less.

Treatment with Liraglutide is in the following cases:

In overweight patients, with a BMI between 27 and 30 kg/m2 who present some comorbidity.
In patients with obesity, that is, a BMI > 30 Kg/m2.

What Are Liraglutide Results?

A decrease in weight happens when hunger loss occurs, and an increase in the sense of satiety. The action plan of the drug and the obtaining of results must always include a balanced diet and physical exercise. In this way, it will achieve the objective, and you will be able to get the most out of the treatment.

Liraglutide Benefits

By reducing excess weight, other health problems frequently associated with overweight and obesity, such as high blood pressure, high blood sugar levels and sleep difficulties, such as sleep apnea, improve.

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What Is liraglutide Weight Loss Peptide?

A doctor will provide you with a personalized schedule and monitor you during the other check-ups.

What Are Liraglutide Side Effects?

If side effects occur, the most common are nausea, vomiting, constipation or diarrhoea, but they usually disappear after a few days.

How Much Weight Can You Lose With Liraglutide?

The anti-obesity drug helps reduce weight by around 15%. Europe has just approved a treatment for obesity that is already working successfully in the United States. The drug is injected like insulin and allows you to reduce your weight by around 15%.  It decreases the appetite  and improves motivation, and injected with a system similar to insulin for people with diabetes. A loss of around 15% of the weight is achieved in a year.
In the United States, where it was approved in June 2021, the first batches were sold out despite the fact that the price is around one thousand euros.

What Does WEGOVY Consist Of?

Wegovy is the trade name given to it by the pharmaceutical company, the Danish Novo Nordisk. The generic name of the drug is semaglutide. It has already been used as a component of other medications for diabetes also to reduce weight.

Regulates Appetite And Improves Cholesterol And Glucose Levels

It is a mimic of a human gut hormone, GLP-1. This hormone is activated when eating and is responsible for stimulating the pancreas to secrete insulin.

Wegovy helps create insulin to assimilate food better: it improves cholesterol and glucose levels.
It is also a neurotransmitter: it signals the brain to regulate hunger. The feeling of hunger is reduced.

A side effect is that the person feels better and sees that they eat less, which motivates them to continue the treatment and diet.

It is a mimic of a human gut hormone, GLP-1. This hormone is activated when eating and is responsible for stimulating the pancreas to secrete insulin.

New Weight Loss Treatment – Liraglutide Results

Do not forget that a treatment like this cannot be taken as a magical solution to the weight problem. It has to be accompanied by an improvement in lifestyle and diet. So, what can be done (and not done) to fight obesity? It is the combination of exercise and diet and the drug (administered with the insulin pen once a week) that manages to lose weight.

In clinical studies, 4,000 obese volunteers were followed for two years. Some were given Wegovy and others placebo.

Shortly after one year (at 68 weeks of treatment):

86% had lost at least 5% weight. In the placebo group, it was 31%.
More than half of those taking the drug lost 15% of weight. They were only 5% in the placebo group.
38% managed to lose up to 20% of weight. In the placebo group, the number was not significant.

Who Needs Liraglutide?

This medication is not intended as an aid to take a short time, get to a proper weight and forget about it. It is a treatment for people with chronic obesity and the treatment is long-term. We are talking about results after one or two years.

It is not a punctual treatment for overweight, but for people with obesity

Different drug regulatory agencies differ in their recommendations. The European EMA recommends it to obese people with a Body Mass Index greater than 30.

The index from 18.5 to 24 is considered normal. 25 to 30 is overweight. And from 30 is obesity.
In cases where there is an associated disease, such as diabetes or high cholesterol, the prescription of the drug is admitted from an index of 27.

In the United States and Canada they follow this recommendation. But in the UK it has been approved only for cases with an index greater than 35.

With an index of 35 to 40 in our country, surgery is already recommended for a stomach reduction. Early treatment of obese people would prevent these extremes and many operations from being reached.

Is There Any Problems?

It is a well-known treatment because it has been used in other treatments with diabetes. The main difference is that with similar drugs, people with diabetes had not achieved as good results as those shown by Wegovy.

However, obese people with diabetes do not lose as much weight as those who are just obese.

Is Liraglutide Approved For Weight Loss?

The drug must also be taken with caution during the first four months. The amount is progressively increased as it can cause some side effects:

• Intestinal problems: diarrhea, nausea and vomiting
• Causes tiredness
• Headache

However, the biggest problem is the economic one since the Public Health does not pay for slimming drugs. And the case of the Wegovy, being new, is costly. In the United States, it is sold for a thousand euros a month. Its commercialization has not yet been generalized in Europe.