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GLP-1 subdues the total glucagon secretion. It is a naturally occurring short peptide hormone whose primary function is to reduce blood sugar levels by enhancing insulin secretion. The most crucial focus of the research GLP-1 peptide research is to prevent and treat diabetes. Additional studies are finding it to have practical benefits in cardiovascular and neurodegenerative diseases.
GLP-1 agonists assist glucose-insulin secretion, slow gastric motility, and reduce glucagon levels following meals. These can result in hypoglycemic effects even following intravenous administration, without hypoglycemia GLP-1 agonist.
What is Type 2 Diabetes?
People with type 2 diabetes mean blood glucose or sugar is higher than average. Glucose in the blood comes mainly from the food eaten, and the liver makes a small portion. It is usual for the glucose level to rise after a meal. But with diabetes, the level can get too high.
The body uses glucose for energy with the help of insulin, a hormone made by the pancreas. Type 2 diabetes can occur when the body:
- Does not produce enough insulin
- Not using insulin properly
Older and middle-aged people are more prone to diabetes type 2. Lack of physical activity and being overweight can also increase the risk of type 2 diabetes.
Over time, high glucose can lead to significant health problems, such as eye and nerve damage, heart attacks, strokes, and kidney disease. But health problems can be avoided or delayed by keeping blood glucose, blood pressure, and cholesterol within acceptable ranges. Meal planning, exercise, and medicine (if needed) can help you stay healthy.
Incretin-acting drugs are a form of medication for type 2 diabetes. The treatment relies on the workings of the hormones called incretins. These help manage the job of the pancreas. A form of incretin called GLP-1 causes the pancreas to make extra insulin after food and helps keep the blood glucose level within the usual range.
What are GLP-1 receptor agonists?
GLP-1 receptor agonists are also called incretin mimetics and are a medicine with incretin action. The medication mimics the activity of GLP-1 made by the body. The effects of GLP-1 last only a few minutes, but GLP-1 receptor agonists can last up to 10 hours.
GLP-1 receptor agonists come in a liquid form to inject under the skin of the stomach, thigh, or arm. Depending on the medicine prescribed for diabetes, they can be injected once or twice a day or once a week. GLP-1 receptor agonists are used alone or with additional diabetes medications.
People with diabetes need to be acquainted with what to eat or drink to keep their glucose level within the acceptable range.
GLP-1 Receptor Agonists Benefits
- GLP-1 receptor helps stop glucose from getting too high
- Increase the insulin made by the pancreas
- Decrease glucagon
- Helps give a feeling of fullness after eating helping to eat less
- Slows down the emptying of stomach contents into intestines
- Lowers blood glucose level after eating.
What are the side effects and disadvantages of GLP-1 receptor agonists?
GLP-1 receptor agonists do not cause low blood glucose (hypoglycemia). But they run the threat of lowering the glucose if you also take diabetes pills or insulin that can cause hypoglycemia. A low glucose level can boost hunger or cause dizziness, nervousness, shakes, or confusion.
Those with diabetes have to learn what to eat or drink to get their glucose levels back to normal.
Exenatide and liraglutide can cause nausea, vomiting, diarrhea, headache, weakness, or dizziness. Some side effects are signs of severe disorders, such as nausea and vomiting, with abdominal pain may indicate the inflammation of the pancreas.