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Where Can I Find Follistatin?
Follistatin is a substance in the body that is made up of protein and sugar. It is known as a glycoprotein and mainly produced in the liver but is in most of the body’s tissues. Its primary function is to increase muscle and increase cell growth. There are varying forms of follistatin in the body that have different processes. These include Follistatin-344, the most basic structure found in gene therapy. The main Follistatin for sale for study are:
- Follistatin-315 is in the bloodstream and mainly targets muscle tissue.
- Follistatin-288 plays a part in reproductive health. It also plays a role in tumors and cancer cell development.
- Follistatin-300 is a type of follistatin linking to nerve connections and cardiac inflammation.
Follistatin works by blocking different hormones and proteins, such as:
- Activins are responsible for – bone growth, endocrine homeostasis, metabolism, cancer development, cancer cells, and fibrosis inflammation
- Myostatin is responsible for stopping muscle growth
- GDF-11 is a growth factor in bone growth
- FSH or follicle-stimulating hormone that is responsible for the forming of eggs and sperm
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What is Follistatin 288?
Follistatin is a naturally occurring protein used to treat fertility problems in both men and women. It can treat women with ovarian problems. Thus for a short time, this can help women ovulate more eggs and give them the best chance of becoming pregnant. Follistatin is often used to help women with fertility issues because of blocked or damaged fallopian tubes, endometriosis, polycystic ovary syndrome (PCOS), and some types of ovarian cancer. The follistatin 288 is from humans and does not combine with other proteins.
What are the Benefits of Follistatin?
For those unable to conceive naturally after trying for two years, it is possible to increase your chance of becoming pregnant. This treatment can help both women and men, and some men can use follistatin to increase the chances of pregnancy. This treatment may also be able to boost egg quality. If you are trying to get pregnant after several treatment cycles, it is also possible that follistatin may help ovulate more eggs. Follistatin is a new type of fertility treatment for women with infertility issues. It is usually only given to women and started before your second or third treatment cycle.
What are the risks of Follistatin?
This treatment is the first cycle of treatment. So it means you won’t start your treatment cycle until you are ovulating normally. As follistatin is part of a cycle of treatment, getting pregnant is higher than if you began a treatment process before you had any fertility issues. The use of follistatin in a treatment cycle will also give you a higher chance of achieving pregnancy after one cycle of treatment.
Follistatin Results
The most common side effects include increased hair growth, acne, and facial hair. Some women may also develop ovarian cysts after treatment, but it is more common for women to stop ovulating after starting follistatin. It means that follistatin will not help them to get pregnant. As follistatin is usually is not taken for long periods, women do not often experience any side effects from this treatment.
What is follistatin 344 used for?
The peptide Follistatin-344, is an artificial research peptide derived from human follistatin. Studies show Follistatin-344 blocks myostatin and increase muscle mass. It shows promising results as a possible treatment in the future for muscle wastage diseases.
Does Follistatin Really Work?
Studies so far show trials with follistatin stop Myostatin and increase muscle mass—a massive discovery in medicine for treating muscle loss and wastage diseases.
Follistatin is a naturally occurring protein that functions as an endogenous inhibitor of activin. Activin is a member of the transforming growth factor-beta (TGF-beta) superfamily synthesized and secreted by many cell types, including T-cells. When activated, it binds to cell surface receptor complexes. It mediates multiple biological processes, including:
-cell proliferation
-differentiation
-migration
-angiogenesis
-apoptosis
-cell motility
-extracellular
-matrix deposition
-cell-to-cell contact
-bone formation
What is follistatin 344 used for?
Follistatin can inhibit all three isoforms of activin by two different mechanisms. It binds activin and blocks binding to activin receptor complexes. Follistatin also competes with endogenous activin for binding to its receptors, thus competitively inhibiting the action of activin. It binds to activin receptors but does not function as an activin ligand.
What is the Mechanism of Action of Follistatin in cancer?
Follistatin competitively inhibits activin. It has an immunosuppressant effect with a positive impact on immune cell trafficking. So its use in cancer immunotherapy is effective. Inflammatory and anti-angiogenic properties, which inhibit tumor progression. In animal models, studies show:
-follistatin prevented angiogenesis of implanted tumors
-reduced angiogenesis associated with non-melanoma skin cancer
-inhibited growth and angiogenesis in breast and prostate cancer.
In humans, anti-follistatin antibodies that neutralize the anti-angiogenic activity of follistatin happen in clinical trials in various cancers. They include breast, ovarian, and colon cancer. Several clinical trials show follistatin reduces serum levels of vascular endothelial growth factor (VEGF), so it redcues the tumor volume in breast, colon, and renal cell carcinoma. The clinical relevance of this observation remains unclear, and clinical trials show follistatin works well.
