People who struggle to get pregnant or have low testosterone levels will undoubtedly know about HCG or Human Chorionic Gonadotropin. In the case of HCG, the previous few years have seen the FDA put stricter restrictions on HCG, making it harder for patients to access. In many cases, the FDA is stopping HCG use altogether. For many people needing this treatment, the low supply of HCG forces them to seek higher-cost brand-name treatments. Or even worse, go without essential medication.
A Guide To Gonadorelin Fertility
How Does Gonadorelin Work?
Gonadorelin can test how well the hypothalamus and pituitary glands are working[2]. The gonadotropin-releasing hormone works on the anterior pituitary gland. It signals the pituitary gland to release the follicle-stimulating hormone and luteinizing hormone.
FSH and LH hormones work on the testes in men’s and women’s ovaries. These hormones cause the testes to develop to make sperm and ovaries mature. Follicle-stimulating hormones and luteinizing hormones encourage the testes and ovaries to release hormones.
For example, the testes release estrogen and testosterone, and the ovaries release estrogen, progesterone, and testosterone. The GnRH release is in pulses, and in men, this is at a consistent rate.
But, in women, the GnRH pulses are variable due to the menstrual cycle. A typical example is before ovulation GnRH occur more often.
Gonadorelin is a similar compound to HCG and works in the same way. But for now, it is less popular than HCG, but one day could become a better option.
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Does Gonadorelin Increase Sperm Count?
In studies[3], Gonadorelin proves to be very effective in increasing sperm count. Gonadorelin increases LH luteinizing hormone and FSH follicle-stimulating hormone, whereby HCG does not. It stimulates the pituitary gland essential for producing testosterone in the testicles.
Gonadorelin significantly boosts testosterone production in the same way as puberty. The body is at its peak during puberty in hormone secretion for essential growth and sexual development. Ultimately, Gonadorelin benefits men by improving testicular atrophy and increasing seminal volume.
With IVF, the doctor has to regulate the ovulation cycle, so eggs don’t ovulate too soon. Then they would be unable to retrieve them for fertilization in the embryology laboratory, so doctors give a GnRH agonist or antagonist. These treatments cause a short-term state of menopausal but differ in how they work.
GnRH agonist initially causes an increase in FSH and LH hormones, and then they stop. The GnRH antagonist has no surge in the first stage. After this, the patient inserts the IVF treatment to encourage the ovaries to produce eggs.
- GnRH agonists are: Lupron, Synarel, Suprecur and Zoladex
- GnRH antagonists include: Antagon, Cetrotide, Ganirelix and Orgalutran
Research Uses: Gonadorelin HCG
HCG is predominately a treatment in women to encourage natural ovulation and increase fertility. It can also diagnose tumors related to the reproductive system. HCG can also increase fertility in men, alongside a testosterone treatment.
Gonadorelin is still in the research stage and is a similar treatment to HCG. Further studies show Gonadorelin effectively slows cancer growth in some forms of breast cancer[4]. In addition, some experts are finding it may be a possible preventative treatment for breast cancer. There is a chance Gonadorelin may reduce the risk of breast cancer by half if used for over ten years.
Positive feedback is that high amounts Gonadorelin can slow down aggressive prostate cancer by inhibiting testosterone production.
Gonadorelin vs HCG TRT – The Facts
Gonadorelin and HCG both work well to boost testosterone levels in men.
HCG increases testosterone[5], stabilizes fertility, stops testicular shrinkage, boosts libido, and improves brain function. Men undergo testosterone replacement therapy or TRT to treat low testosterone levels due to age or illness.
TRT can treat male hypogonadism when the body testes don’t make enough testosterone for masculine development, sperm count, and puberty. Usually, these problems occur due to age or medical problems.
But side effects can arise with TRT, and HCG can help reduce them by maintaining fertility and further halting testicles’ shrinking. HCG will stimulate the testicles to make testosterone, sperm and estrogen.
Similarly, Gonadorelin also improves testicle function and stops testicle shrinkage. At the same time maintains testicular function and size, and position, prompting estrogen, sperm and testosterone production.
Alternatively, Gonadorelin will not shrink testicles when using TRT but want to keep their fertility and testosterone while on TRT. To summarize, Gonadorelin is suitable for maintaining testicular size, fertility, sperm count and ejaculation.
Does Gonadorelin Increase Testosterone?
Gonadorelin is a gonadotropic releasing hormone (GnRH). It is the synthetic version of the body’s natural neuropeptide, made in the hypothalamus in the brain. Healthy young males continually produce natural gonadorelin. It releases only every two hours in pulses from the hypothalamus. The neuropeptide moves to the anterior pituitary gland. It acts as a response, stimulating pulses from the luteinizing hormone, follicle-stimulating hormone, and tiny amounts of human chorionic gonadotropin (HCG).
These specific hormones move from the anterior pituitary to the testicles to promote the production of estrogen, testosterone[6] and sperm.
Generally, Gonadorelin can help in males with testosterone deficiency, low testosterone levels and decreased fertility. Patients with low testosterone levels have smaller-than-average testicles in many circumstances. It is widespread in older men. But, it is crucial for young males to make their own testosterone and maintain fertility.
Why Prescribe Gonadorelin For Men?
In most cases, Gonadorelin[7] is the first recommendation for men who don’t want testicular atrophy when using TRT. But, it can also help men maintain fertility and produce normal testosterone levels when using TRT. However, as with many treatments, there are no guarantees, and it is not always possible to stop testicular atrophy, whether on gonadorelin HCG or other therapies such as enclomiphene citrate.
Gonadorelin With TRT
For many aging men, it is inevitable they will likely suffer from low levels of hormones and testosterone. With this, men get told by doctors there is little to be done and blame aging factors. Alternatively, some are recommended testosterone replacement therapy and forced to suffer the consequences of loss of fertility and testicular atrophy. But, new treatments, like Gonadorelin[8], show promising results in treating the side effects of TRT in similar ways to HCG.
Does Gonadorelin Have Side Effects?
The research peptide Gonadorelin is a treatment to stop testicular shrinkage when taking TRT, preserving fertility and ensuring they produce their testosterone. To date, studies find Gonadorelin a relatively safe treatment. But, as with all medication, discussing any other medicines you may be taking with your doctor before using Gonadorelin is essential. The main side effects[9] experienced by patients from taking Gonadorelin are:
-Dizziness
-Flushing
-Headaches
-Irritation, itching, and swelling
-Nausea
-Skin rash
Gonadorelin Reviews
Natural peptides exist in all living organisms and act as antibodies, enzymes and hormones[10]. Research peptides are made in the laboratory and are derivatives of these natural peptides. There are a lot of different research peptides that can help with various age-related conditions and diseases.
Gonadorelin is effective in men and women in promoting the release of sex hormones and estrogen and can increase sperm count. The hormone plays a part in developing secondary sex properties, including breast growth and facial hair.
We already know Gonadorelin increases testosterone, produces more sperm, stops testicular atrophy, and improves fertility rate. But it can also increase muscle mass, strength and endurance.
More Gonadorelin Benefits for Men and Women
There are many Gonadorelin benefits[1], such as treating infertility and the chronic condition of endometriosis which causes horrendous pelvic pain and leads to infertility in women.
Gonadorelin can treat precocious puberty, where puberty happens too young. For example, eight years for girls and nine years for boys.
The peptide Gonadorelin can influence egg release from the ovary in women resulting in rhythmic ovulation and helping improve pregnancy. It also shows excellent results such as :
- Enhancing Libido
- Helping treat amenorrhea – lack of menstrual periods
- Improving joint health
- Increase low hormone levels or Hypogonadism
- Improves frame of mind
- Possible breast and prostate cancer treatment
- Help Alzheimer’s disease
Summary of Gonadorelin HCG
Gonadorelin works well with other treatments, including HCG human chorionic gonadotropin. These hormonal treatments travel to women’s ovaries and men’s testes to influence the sex hormones, estrogen in women and testosterone in men. Gonadorelin and HCG are GnRH, which is crucial for men and women in reproduction and sexual development.
Gonadorelin and HCG are two similar treatments that work alike. But they are not the same. Gonadorelin has many advantages: it is cheap to produce, has simple but long storage needs, and has minimal side effects. On the other hand, HCG has few therapeutic benefits and is primarily for testing.
HCG is also known as the pregnancy hormone. The placenta makes human chorionic gonadotropin in pregnancy, helps strengthen the uterine line to aid the developing embryo, and informs the body to stop periods. It is known as the pregnancy hormone. Human chorionic gonadotropin in men increases testosterone and sperm production. There is also evidence it helps with penile growth and testicular atrophy.
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Resources
[1] Successful fertility treatment with gonadotrophin therapy for male hypogonadotrophic hypogonadism
J Rajkanna, S Tariq, and S O Oyibo
[2] gonadorelin: Generic name: gonadorelin (injectable) [ gon-ah-doe-REH-lin ] Brand names: Factrel, Lutrepulse Drug class: Gonadotropin releasing hormones
[3] Gonadorelin increases semen production and does not affect its quality in Leporinus obtusidens
Author links open overlay panelJurandir JoaquimBernardes JúnioraRobie AllanBombardellibAlex Pires de OliveiraNuñera
[4] GONADORELIN – IS THIS A SUPERIOR ALTERNATIVE FOR HCG? A novel approach to breast cancer prevention: reducing excessive ovarian androgen production in elderly women PMID: 27393623 DOI: 10.1007/s10549-016-3901-1
[5] Human Chorionic Gonadotropin Danielle Betz; Kathleen Fane. doi: 10.3109/09513599309152490.
Comparison of hCG versus GnRH analog for releasing oocytes following ultra low-dose gonadotropin stimulation. Risks of testosterone replacement therapy in men E. Charles Osterberg, Aaron M. Bernie, and Ranjith Ramasamy
[6] Gonadorelin-induced testosterone release: a biological assay for quality assurance of gonadorelin in veterinary medicine D J Kesler 1, R N Summers, C A Peterson, T L Steckler
[7] The National Center for Advancing Translational Sciences (NCATS) has developed Inxight Drugs as a comprehensive portal for drug development information.
Further Resources
[8]Human Chorionic Gonadotropin Danielle Betz; Kathleen Fane. The National Center for Advancing Translational Sciences (NCATS) has developed Inxight Drugs as a comprehensive portal for drug development information.
[9] FACTREL SIDE EFFECTS CENTER Generic Name: gonadorelin
Brand Name: Factrel Drug Class: Gonadotropin Releasing Hormone Agonists
[10] The effects of 3 gonadorelin products on luteinizing hormone release, ovulation, and follicular wave emergence in cattle
Marcelo F. Martínez, Reuben J. Mapletoft, John P. Kastelic, and Terry Carruthers
[11] APOE and MS4A6A interact with GnRH signaling in Alzheimer’s disease: Enrichment of epistatic effects
Alejandro Cáceres 1, José E Vargas 2, Juan R González 3
Effect of gonadorelin, lecirelin, and buserelin on LH surge, ovulation, and progesterone in cattle
Author links open overlay panelN.Picard-HagenabG.LhermiecS.FlorentinaD.MerleaP.FreinaV.Gayrardab
Combined blockade of testicular and locally made androgens in prostate cancer: a highly significant medical progress based upon intracrinology J Steroid Biochem Mol Biol. 2015 Jan;145:144-56.
T Hashimoto, K Miyai Gonadorelin and erythropoiesis
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